Tirzepatide Dosing Guide: Schedule, Titration, and Administration Tips

Proper dosing of tirzepatide is critical for maximizing benefits while minimizing side effects. Here's your complete guide to the dosing schedule and administration.

Available Doses

Tirzepatide is available in six dose strengths:

• 2.5 mg (starting dose)
• 5 mg
• 7.5 mg
• 10 mg
• 12.5 mg
• 15 mg (maximum dose)

Standard Titration Schedule

Important: Each dose increase should occur only if the current dose is well-tolerated. Your provider may slow the titration if you experience significant side effects.

Administration

• Route: Subcutaneous injection (under the skin)
• Frequency: Once weekly
• Injection Sites: Abdomen, thigh, or upper arm
• Timing: Any time of day, with or without food
• Consistency: Inject on the same day each week (can change day if needed with ≥3 days between doses)

Injection Technique Tips

1. Rotate injection sites — don't inject in the same spot repeatedly
2. Allow the pen to reach room temperature before injecting (15-30 minutes)
3. Clean the injection site with an alcohol swab
4. Pinch the skin and insert the needle at a 90-degree angle
5. Hold the pen in place for 10 seconds after the click
6. Don't rub the injection site afterward

Storage

• Unopened: Refrigerate at 36°F to 46°F (2°C to 8°C)
• In use: Can be kept at room temperature (up to 86°F/30°C) for up to 21 days
• Do not freeze — discard if frozen
• Protect from light and direct heat

Missed Dose Protocol

• If missed by <4 days: Take as soon as remembered
• If missed by ≥4 days: Skip the missed dose and take the next dose on the regular schedule
• Never take two doses within 3 days of each other